Abstract
To clarify the relationship between cardiac energy metabolism and electrolytes changes in cardiac muscle, the author investigated the changes of the coronary A-V difference of electrolytes caused by the drip infusion of Ringer's solution and 10% sodium pyruvate solution. Then the differences between electrolyte contents in the normal and the experimental coronary insufficient dog were observed. Furthermore, the changes of the coronary A-V differences of electrolytes in the experimental coronary insufficient dog, and the effects of TTFD, TATD, cytocharome c, vitamin B_<15>-like substance, vitamin B_T, uridine on that coronary A-V differences were observed, too. Simultaneously the coronary A-V differences of pyruvate, lactate, α-ketoglutarate were determined. (1) When the normal dog was drip infused by 10% sodium pyruvate, the coronary A-V difference of electrolytes was improved in the beginning and followed by gradual disturbance. (2) Compared to the normal left ventricular tissue, the coronary insufficient left ventricular tissue was elevated in the contents of sodium, and decreased in the contents of potassium. (3) The coronary A-V differences of sodium showed maximum peak at the 7 minutes after incomplete ligation of coronary artery, at the l4 minutes after a slight decrease, and then followed by a gradual increase. Compared to sodium, potassium was observed almost reversely. (4) Disturbances of electrolytes metabolism above described was improved by administration of vitamins and others. This improvement was paralled with improvement of carbohydrate metabolism in cardiac muscle. From the experimental results and referencial considerations, it is conceivable that the differences of electrolyte contents between intra and extra cardiac cellular space depend upon energy metabolism in cardiac muscle.
