Abstract
Influences of daily administration of a large amount of thiamine, thiamine tetrahydrofurfuryl disulfide (TTFD), riboflavin and pyridoxine to rats for a month were investigated by observations on the growth of rats, the biosynthesis of protein-bound lipoic acid in liver mitochondria and the activity of glutamic oxalacetic transaminase in liver homogenate. Overdose of thiamine (1,10 and 50mg/kg) and TTFD (1 and 10mg/kg) induced an increased biosynthetic activity of protein-bound lipoic acid, but over-dose of TTFD (50mg/kg) and pyridoxine induced a decreased biosynthetic activity. Over-dose of riboflavin did not effect the biosynthetic activity of protein-bound lipoie acid. The activity of glutamic oxalacetic transaminase was not affected in those states.
