Abstract
The present authors investigated the influences of the administration of a thiamine derivative as thiamine monophosphate disulfide (TMPDS) on the fetus in pregnant experimental animals and its youngs, according to the test method of the influences of new drug on fetus. TMPDS was given intraperitoneally 20mg per kg (small dose group), 100 mg per kg (intermediate dose group), 200 mg per kg (large dose group) during 7〜12th day in pregnant ICR mice and 9〜14th day in pregnant Wistar-Imamichi rat, every day. TMPDS results in malformations such as cleft plate, curve of tail, etc., in mice at large dose. Malformation could not be observed in rats. Nevertheless, when it was given within the range of 10 to 100 times of proposed therapeutic dose, the administration of TMPDS does not have any inhibitory effect on the development of fetus in pregnant mice and rats or their youngs.
