STUDIES ON THIAMINE PHOSPHATES : (IX) STUDIES ON THE TOXICITY OF THIAMINE MONOPHOSPHATE DISULFIDE

Abstract

Chronic toxicity tests were made on thiamine monophophate disulfide (TMPDS). TMPDS was administered subcutaneously, 5.16,51.6 and 412.8 mg/kg/day for 12 weeks in Wistar-Imamichi rats and 51.6 mg/kg/day for 4 weeks in dogs. No effect on the general symptoms and clinical and histo-pathology was observed.