Abstract
The fate of tetrahydrofurfurylsulfide-^<35>S group of thiamine tetrahydrofurfuryldisulfide-^<35>S in rat was investigated. The side chain of the thiamine derivative was considered to be separated from thiamine molecule by reducing substances in blood after the absorption from the intestinal canals, and then excreted in urine as its metabolized products. Six metabolites were found in the rat urine by paper chromatography and paper electrophoresis. One of them was sulfate-^<35>S (about 30% of admintstered ^<35>S) and the others (about 70%) were soluble in ethanol or butanol but insoluble in benzene. It is considered that part of the metabolites combined with albumin in blood.
