STUDIES ON THE ABSORPTION OF ^<57>Co-LABELED HYDROXOCOBALAMIN : (II) INTRINSIC FACTOR DEPENDENCE AND ABSORPTION IN MAN

Abstract

Hydoxocobalamin-^<57>Co was given per os to man and absorption was determined both by the fecal and the urinary excretion methods. It was found that the absolute absorption was about the same as but the urinary excretion was much less than that of cyanocobalamin. Adsorption of a physiological dose by subjects after total gastrectomy was very small and coadministration of hog intrinsic factor increased absorption appreciably. The study using the rat loop technique (Okuda) disclosed that absorption of hydroxocobalamin was intrinsic factor dependent to the same extent as cyanocobalamin.