VITAMINS
Online ISSN : 2424-080X
Print ISSN : 0006-386X
Search
Advanced search
OR
Browse
Search
Volume 33, Issue 3
Displaying 1-26 of 26 articles from this issue
Show all abstracts
    • |<
    • <
    • 1
    • >
    • >|
  • [title in Japanese]
    [in Japanese]
    Article type: Article
    1966 Volume 33 Issue 3 Pages 217-218
    Published: March 25, 1966
    Released on J-STAGE: February 09, 2018
    DOIhttps://doi.org/10.20632/vso.33.3_217
    JOURNAL FREE ACCESS
    Download PDF (699K)
  • [title in Japanese]
    [in Japanese]
    Article type: Article
    1966 Volume 33 Issue 3 Pages 219-225
    Published: March 25, 1966
    Released on J-STAGE: February 09, 2018
    DOIhttps://doi.org/10.20632/vso.33.3_219
    JOURNAL FREE ACCESS
    Download PDF (787K)
  • [title in Japanese]
    [in Japanese]
    Article type: Article
    1966 Volume 33 Issue 3 Pages 226-228
    Published: March 25, 1966
    Released on J-STAGE: February 09, 2018
    DOIhttps://doi.org/10.20632/vso.33.3_226
    JOURNAL FREE ACCESS
    Download PDF (517K)
  • [title in Japanese]
    [in Japanese]
    Article type: Article
    1966 Volume 33 Issue 3 Pages 229-230
    Published: March 25, 1966
    Released on J-STAGE: February 09, 2018
    DOIhttps://doi.org/10.20632/vso.33.3_229
    JOURNAL FREE ACCESS
    Download PDF (294K)
  • [title in Japanese]
    [in Japanese]
    Article type: Article
    1966 Volume 33 Issue 3 Pages 231-232
    Published: March 25, 1966
    Released on J-STAGE: February 09, 2018
    DOIhttps://doi.org/10.20632/vso.33.3_231
    JOURNAL FREE ACCESS
    Download PDF (333K)
  • [title in Japanese]
    [in Japanese]
    Article type: Article
    1966 Volume 33 Issue 3 Pages 233-235
    Published: March 25, 1966
    Released on J-STAGE: February 09, 2018
    DOIhttps://doi.org/10.20632/vso.33.3_233
    JOURNAL FREE ACCESS
    Download PDF (429K)
  • [title in Japanese]
    [in Japanese]
    Article type: Article
    1966 Volume 33 Issue 3 Pages 236-238
    Published: March 25, 1966
    Released on J-STAGE: February 09, 2018
    DOIhttps://doi.org/10.20632/vso.33.3_236
    JOURNAL FREE ACCESS
    Download PDF (450K)
  • [title in Japanese]
    [in Japanese]
    Article type: Article
    1966 Volume 33 Issue 3 Pages 239-242
    Published: March 25, 1966
    Released on J-STAGE: February 09, 2018
    DOIhttps://doi.org/10.20632/vso.33.3_239
    JOURNAL FREE ACCESS
    Download PDF (1013K)
  • [title in Japanese]
    [in Japanese]
    Article type: Article
    1966 Volume 33 Issue 3 Pages 243-245
    Published: March 25, 1966
    Released on J-STAGE: February 09, 2018
    DOIhttps://doi.org/10.20632/vso.33.3_243
    JOURNAL FREE ACCESS
    Download PDF (436K)
  • [title in Japanese]
    [in Japanese]
    Article type: Article
    1966 Volume 33 Issue 3 Pages 246-250
    Published: March 25, 1966
    Released on J-STAGE: February 09, 2018
    DOIhttps://doi.org/10.20632/vso.33.3_246
    JOURNAL FREE ACCESS
    Download PDF (355K)
  • [title in Japanese]
    [in Japanese]
    Article type: Article
    1966 Volume 33 Issue 3 Pages 251-254
    Published: March 25, 1966
    Released on J-STAGE: February 09, 2018
    DOIhttps://doi.org/10.20632/vso.33.3_251
    JOURNAL FREE ACCESS
    Download PDF (568K)
  • [title in Japanese]
    [in Japanese]
    Article type: Article
    1966 Volume 33 Issue 3 Pages 255-262
    Published: March 25, 1966
    Released on J-STAGE: February 09, 2018
    DOIhttps://doi.org/10.20632/vso.33.3_255
    JOURNAL FREE ACCESS
    Download PDF (1352K)
  • [title in Japanese]
    [in Japanese]
    Article type: Article
    1966 Volume 33 Issue 3 Pages 263-268
    Published: March 25, 1966
    Released on J-STAGE: February 09, 2018
    DOIhttps://doi.org/10.20632/vso.33.3_263
    JOURNAL FREE ACCESS
    Download PDF (1271K)
  • STUDIES ON THE ABSORPTION OF ^<57>Co-LABELED HYDROXOCOBALAMIN : (I) COMPARISON WITH CYANOCOBALAMIN AND ESTABLISHMENT OF PROCEDURE FOR DOUBLE TRACER STUDY
    Kunio OKUDA, Jichio MATSUURA, Hikaru HIRATSUKA, Michio UCHIDA, Yahiko ...
    Article type: Article
    1966 Volume 33 Issue 3 Pages 269-274
    Published: March 25, 1966
    Released on J-STAGE: February 09, 2018
    DOIhttps://doi.org/10.20632/vso.33.3_269
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    The first half of the study deals with the establishment of the laboratory procedure and conditions for measuring ^<57>Co and ^<60>Co in fecal matter, particularly with regard to the gamma spectrometric separation of the two isotopes and necessary corrections. The second half is concerned with the measurement of intestinal absorption of hydroxocobalamin-^<57>Co in comparison with cyanocobalamin-^<60>Co in rats following oral administration, and organ uptakes of radioactivity. No difference was obtained in the absolute amount of absorption between the two analogues, but the radioactivity uptakes by the liver and kidney were greater following administration of hydroxocobalamin-^<57>Co than cyanocobalamin-^<60>Co.
    View full abstract
    Download PDF (1037K)
  • [title in Japanese]
    [in Japanese]
    Article type: Article
    1966 Volume 33 Issue 3 Pages 274-
    Published: March 25, 1966
    Released on J-STAGE: February 09, 2018
    DOIhttps://doi.org/10.20632/vso.33.3_274
    JOURNAL FREE ACCESS
    Download PDF (171K)
  • STUDIES ON THE ABSORPTION OF ^<57>Co-LABELED HYDROXOCOBALAMIN : (II) INTRINSIC FACTOR DEPENDENCE AND ABSORPTION IN MAN
    Kunio OKUDA, Jichio MATSUURA, Hikaru HIRATSUKA, Yahiko IKOMA, Keitoku ...
    Article type: Article
    1966 Volume 33 Issue 3 Pages 275-279
    Published: March 25, 1966
    Released on J-STAGE: February 09, 2018
    DOIhttps://doi.org/10.20632/vso.33.3_275
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    Hydoxocobalamin-^<57>Co was given per os to man and absorption was determined both by the fecal and the urinary excretion methods. It was found that the absolute absorption was about the same as but the urinary excretion was much less than that of cyanocobalamin. Adsorption of a physiological dose by subjects after total gastrectomy was very small and coadministration of hog intrinsic factor increased absorption appreciably. The study using the rat loop technique (Okuda) disclosed that absorption of hydroxocobalamin was intrinsic factor dependent to the same extent as cyanocobalamin.
    View full abstract
    Download PDF (588K)
  • STUDIES ON BEEF LIVER CATALASE : (I) FLUORESCENT SUBSTANCE IN PARTIAL ACID HYDROLYSATE OF CATALASE
    Michiko YAGI
    Article type: Article
    1966 Volume 33 Issue 3 Pages 280-289
    Published: March 25, 1966
    Released on J-STAGE: February 09, 2018
    DOIhttps://doi.org/10.20632/vso.33.3_280
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    Beef liver catalase prepared by the method of Deutsch was further purified by DEAE-cellulose chromatography and Sephadex G-200 gel filtration. The fluorescence spectrum of partial acid hydrolysate of the catalase preparation suggested that flavin-like substance might be contained in the enzyme. Paperchromatographic isolation of the substance with the flavin-like fluorescence was attempted. Paperchromatographic behavior, fluorescence spectrum, and absorption spectrum of the isolated material suggested that the substance might be flavinnucleotide.
    View full abstract
    Download PDF (1150K)
  • INHIBITION OF ENZYMATIC ACTIVITY OF BEEF LIVER CATALASE BY FLAVINMONOSULFATE AND ADENOSINESULFATE
    Michiko YAGI
    Article type: Article
    1966 Volume 33 Issue 3 Pages 290-292
    Published: March 25, 1966
    Released on J-STAGE: February 09, 2018
    DOIhttps://doi.org/10.20632/vso.33.3_290
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    D-Amino acid oxidase of which coenzyme is FAD is inhibited by flavinmonosulfate or by adenosine monosulfate, according to Egami, et al. The purified ox-liver catalase preparation is supposed to contain FAD as previously reported. The author studied the inhibitory action of these sulfate on catalase activity. It was found that these compounds showed slight inhibition and the inhibitory action was dependent on pH and ionic strength of the reaction medium.
    View full abstract
    Download PDF (336K)
  • ON THE PHOSPHORYLATION OF TOXOPYRIMIDINE BY PYRIDOXAL KINASE OF MOUSE BRAIN
    Michiko TSUBOSAKA
    Article type: Article
    1966 Volume 33 Issue 3 Pages 293-297
    Published: March 25, 1966
    Released on J-STAGE: February 09, 2018
    DOIhttps://doi.org/10.20632/vso.33.3_293
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    It was found that toxopyrimidine, which was one of the vitamin B_6 antagonist, inhibited competitively pyridoxal kinase of mouse brain. Toxopyrimidine was phosphorylated by partially purified pyridoxal kinase to toxopyrimidine phosphate, which was confirmed by paperchromatography, ultraviolet absorption spectrum and quantitative analysis of the phosphoric acid.
    View full abstract
    Download PDF (533K)
  • BIOLOGICAL STUDIES ON PANTETHINE : (I) EFFECT OF PANTETHINE ON THE GROWTH OF RAT
    Yasuo OSHIMA, Akira KASAHARA, Akimoto YAMADA, Yasuaki OSADA, Yasushi A ...
    Article type: Article
    1966 Volume 33 Issue 3 Pages 298-306
    Published: March 25, 1966
    Released on J-STAGE: February 09, 2018
    DOIhttps://doi.org/10.20632/vso.33.3_298
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    Pantethine (PTSS) was examined for its effect on the growth of rats. The albino rats used were males of the Donryu strain produced at the Central Laboratories for Experimental Animals (Tokyo), 27 or 28 days of age and weighing 50 to 60g. They were studied clinically, biochemically, and pathologically, in comparison with three groups of rats fed with different diets, that is pantothenic acid (PaA)-deficient, PaA-added, and normal diet. As a result, the four groups were arranged in the decreasing order of gain in body weight as follows : PTSS>PaA>PaA-deficient>normal. The rats of the PaA-deficient group manifested rough coat, erected hair, rusty-red color of the face, and other signs of PaA-deficiency in accordance in growth. Such changes could not be observed in the PaA group or PTSS group. The CoA content of the liver was very low in the PaA-deficient group, but remained normaly in any other group. The pathological changes by PaA deficiency were apparent in the PaA-deficient group, but not observed in the PaA group or the PTSS group.
    View full abstract
    Download PDF (1908K)
  • INFLUENCE OF THIAMINE PROPYLDISULFIDE ON THE GROWTH OF BACTERIA
    Tutomu HIGASHIURA, Kichitaro FUKUDA, Miyo NAGATA
    Article type: Article
    1966 Volume 33 Issue 3 Pages 307-308
    Published: March 25, 1966
    Released on J-STAGE: February 09, 2018
    DOIhttps://doi.org/10.20632/vso.33.3_307
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    Sixteen kinds of pathogenic bacteria, including Escherichia, Salmonella, Corynebacterium, Neisseria, Streptococcus, Staphylococcus, Diplococcus, Pseudomonas and Vibrio, showed full growth in media containing 5〜100μg/ml of thiamine propyldisulfide. It may be concluded that thiamine propyldisulfide has no effect on the growth of bacteria.
    View full abstract
    Download PDF (273K)
  • STUDIES ON THE METABOLISM OF THIAMINE IN THYROID DISORDERS : (I) CLINICAL STUDIES ON THE METABOLISM OF THIAMINE IN THYROID DISORDERS
    Ryuzo OGAWA
    Article type: Article
    1966 Volume 33 Issue 3 Pages 309-317
    Published: March 25, 1966
    Released on J-STAGE: February 09, 2018
    DOIhttps://doi.org/10.20632/vso.33.3_309
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    A thiamine loading test (subcutaneous injection of 10mg) was performed on 21 patients with hyperthyroidism, 6 patients with hypothyroidism, 8 patients with simple goitre and 10 healthy subjects, as control. Phosphorylated and free thiamines were determined in blood after 30 and 60 min. of injection and also in 3 hrs. urine. In healthy subjects, total thiamine level in fasting blood was 5.1±1.25μg/dl and it increased to 8.3±1.79 μg/dl at one hr. after loading. Ester ratio in blood at that time was 29.5±10.39%. Urinary excretion of thiamine was 40.3±7.59% of administered amount during 3hrs. after injection. In hyperthyroidism, a remarkable increase of esterified thiamine and of ester ratio in blood and a decrease of urinary thiamine after loading as compared with those of controls were observed. On the other hand, in hypothyroidism, a remarkable increases of total blood thiamine and increase of urinary thiamine was found but ester ratio showed only a slight elevation. In all patients, examined, there was inverse correlations between ester ratio and urinary thiamine, total blood thiamine and serum protein-bound iodine, total blood thiamine and basal metabolic rate, respectively. In addition, there was direct correlation between ester ratio and serum protein-bound iodine.
    View full abstract
    Download PDF (781K)
  • STUDIES ON THE METABOLISM OF THIAMINE IN THYROID DISORDERS : (II) METABOLISM OF THIAMINE-^<35>S IN RABBIT
    Ryuzo OGAWA
    Article type: Article
    1966 Volume 33 Issue 3 Pages 318-324
    Published: March 25, 1966
    Released on J-STAGE: February 09, 2018
    DOIhttps://doi.org/10.20632/vso.33.3_318
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    Distribution of ^<35>S was studied in urine and organs of rabbit after an intravenous injection of thiamine-^<35>S. Urinary ^<35>S-compounds were fractionated into thiamine and its metabolites by paper chromatography. About 40% of administered ^<35>S was found in liver 30min. after injection. In testes, heart and brain, ^<35>S contents at 3 hrs. after injection were a little higher than those at 30min. after, while in lung and muscle, it decreased with the lapse of time. Thiamine and ^<35>S in plasma increased promptly after injection and it disappeared with the lapse of time. Thiamine level measured by thiochrome method was higher than that was calculated from ^<35>S until 1 hr. after injection, then it decreased more rapidly. In urine ^<35>S was fractionated in various fractions, such as thiamine, thiochrome, 4-methyl-5β-hydroxymethylthiazole, 4-methyl-5-carboxymethylthiazole and unknown substances. ^<35>S was detected also in bile. Percentages of urinary ^<35>S to administered dose during a period of 30 min., 3 and 5 hrs. after injection, were about 35,46 and 68,respectively. It was revealed that about 54% of ^<35>S, excreted in 5 hrs. urine was in thiamine molecule, while the remainder was in its metabolites, indicating that about one half of thiazole moiety degradated.
    View full abstract
    Download PDF (943K)
  • STUDIES ON THE METABOLISM OF THIAMINE IN THYROID DISORDERS : (III) INFLUENCE OF THYROID HORMONE ON THE METABOLISM OF THIAMINE-^<35>S IN RABBIT
    Ryuzo OGAWA
    Article type: Article
    1966 Volume 33 Issue 3 Pages 325-333
    Published: March 25, 1966
    Released on J-STAGE: February 09, 2018
    DOIhttps://doi.org/10.20632/vso.33.3_325
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    Thiamine-^<35>S was injected intravenously with rabbit of hypermetabolism caused by continuous administration of triiodothyronine or with hypometabolism by thyroidectomy. In hypermetabolic animals, ^<35>S contents of liver, blood, kidney and testes increased although urinary ^<35>S excretion decreased as compared with controls. Urinary excretion of ^<35>S in thiamine metabolites increased more during 5 hrs. following injection than thiamine-^<35>S, indicating that the degradation of thiamine occured a little more progressively than that of controls. These results suggest that hypermetabolic animal was in a state of thiamine deficiency. In hypometabolic animals, ^<35>S content of blood, kidney and lung increased and ^<35>S excreted in urine increased as compaired with controls. Urinary ^<35>S in thiamine metabolite decreased during 5 hrs. after injection, while ^<35>S in thiamine increased than the controls. The results showed that in hypometabolic animal, thiamine deficiency is not seen, and that thiamine simply passes through the animal.
    View full abstract
    Download PDF (2324K)
  • STUDIES ON THIAMINE DISULFIDE : (XIV) DETERMINATION OF O-ACYLTHIAMINE DERIVATIVES BY ACYLTHIOCHROME FLUOROMETRY
    Keiichi KOHNO, Ichimonji SAITO, Isamu UTSUMI
    Article type: Article
    1966 Volume 33 Issue 3 Pages 334-339
    Published: March 25, 1966
    Released on J-STAGE: February 09, 2018
    DOIhttps://doi.org/10.20632/vso.33.3_334
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    A fluorometric procedure for the fractional determination of O-acylthiamine derivatives and thiamine was established by the use of sodium or potassium carbonate as alkali reagent in cyanogen bromide oxidation. Some factors affecting the accuracy of determination were tested and it was found that the salt concentration of the oxidation mixture was an important one. A standard procedure for the mixture of thiamine, OBT, TDS, BTDS were described in table 7. Usefulness and versatility of the acylthiochrome fluorometry were briefly discussed.
    View full abstract
    Download PDF (618K)
  • STUDIES ON THIAMINE DISULFIDE : (XV) METABOLIC PATHWAY OF O-BENZOYLTHIAMINE DISULFIDE TO THIAMINE IN BLOOD AND ITS URINARY EXCRETION
    Keiichi KOHNO, Ichimonji SAITO, Isamu UTSUMI
    Article type: Article
    1966 Volume 33 Issue 3 Pages 340-345
    Published: March 25, 1966
    Released on J-STAGE: February 09, 2018
    DOIhttps://doi.org/10.20632/vso.33.3_340
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    Metabolic pathway of BTDS to thiamine in human blood was investigated in vitro and in vivo, using acylthiochrome fluorometry. BTDS was found to be converted to thiamine mainly through the nonenzymatic reduction by erythrocytes and enzymatic deacylation by plasma. The deacylating activity of plasma was as high as 25 mg OBT per dl per hour at 37℃ and had the optimum pH at 7〜8. Similar enzymatic activities were also detected in homogenates of rat liver and intestine as well as Takadiastase. After oral administration of 300〜50O mg of BTDS on healthy subject, OBT or BTDS was not recognized in blood or urine, and it was concluded that absorbed BTDS was metabolized to thiamine. From these findings the metabolism of BTDS in blood was discussed.
    View full abstract
    Download PDF (669K)
    • |<
    • <
    • 1
    • >
    • >|
feedback
 Top