STUDIES ON O-ACETOGLYCOLOYL-S-FUROYLTHIAMINE : (III) PHARMACOLOGICAL PROPERTIES

Abstract

Among many derivatives of S-acylthiamines synthesized in a series of studies on thiamine, O-acetoglycoloyl-S-furoylthiamine (AFT) was found most remakable in biological properties. In present paper, dynamic pharmacological effects of AFT were studied. Results show that the effect of AFT is milder on acute toxicity of mice, systemic blood pressure and respiration of cats, isolated heasts of toads and excised intestine of guinea pigs, while it has a stronger vasodilating effect of coronary, renal and femoral arteries of dogs than that of thiamine hydrochloride.