STUDIES ON O-ACETOGLYCOLOYL-S-FUROYLTHIAMINE : (IV) DISTRIBUTION OF ^<35>S IN VARIOUS ORGANS AFTER ADMINISTRATION OF O-ACETOGLYCOLOYL-S-FUROYLTHIAMINE-^<35>S AND THIAMINE-^<35>S, STUDIES BY WHOLE BODY AUTORADIOGRAPHY

Abstract

The distributions of O-acetoglycoloyl-S-furoylthiamine (AFT)-^<35>S and thiamine-^<35>S in mice have been studied autoradiographically at various times after an intravenous injection. The results of the autoradiographic distribution are shown in Fig.1-14. When AFT-^<35>S was administered, radioactivities in the heart muscle, skeletal muscles, blood and brain were observed to be higher than in the case of thiamine-^<35>S. In these organs, the ^<35>S of AFT-^<35>S penetrated at higher concentration and was remained for a longer time than the ^<35>S of thiamine-^<35>S.