Abstract
The influence on skeletal muscle fatigue by the massive administration of thiamine-HCl and thiamine tetrahydrofurfuryldisulfide (TTFD) was studied in the rabbits experimentally, and the following results have been obtained. About neuro-muscular transmission and arterial pressure, the effect of TTFD was different from that of thiamine-HCl. In a certain period of time after injection of TTFD 5 mg/kg interavenously, the amplitude of ankle motion on kymograph caused by indirect stimulation was increased, but that was not obtained by the injection of 5 to 7 mg/kg of thiamine-HCl and 5 mg/kg of ATP. The effect perceived through direct stimulation was not evident as through indirect stimulation, even though the equal dosage of TTFD was administered. Therefore, it is presumed that TTFD acts on nerve rather than on muscle.
