Abstract
Based on the previous findings that the bisulfite from sulpyrine caused the replacement reaction of thiamine with the basic moiety of sulpyrine and that the reaction rate was dependent of bisulfite concentration in the system, stabilization of thiamine in the presence of sulpyrine was successfully attempted with the addition of HCHO or HCHO donators such as hexamethylenetetramine. This success may be attributable to decrease in the bisulfite concentration owing to the formation of formaldehyde sodium bisulfite. Partial oxidation of bisulfite in the reaction mixture resulted also in the stabilization of thiamine.
