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Volume 34 (1966)
- Issue 6 Pages 527-
- Issue 5 Pages 459-
- Issue 4 Pages 371-
- Issue 3 Pages 289-
- Issue 2 Pages 175-
- Issue 1 Pages 1-
Volume 34, Issue 3
Displaying 1-23 of 23 articles from this issue
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Gun-ichi KURATA, Tatsuo SAKAI, Tatsuro MIYAHARA, Hiroshi YOKOYAMAArticle type: Article
1966 Volume 34 Issue 3 Pages 289-292
Published: September 25, 1966
Released on J-STAGE: February 09, 2018
JOURNAL FREE ACCESSThe growth of L. fermenti 36 and Kl. apiculata was inhibited by triazinothiamine, 4-[(2-methyl-4-amino-5-pyrimidinyl)-methyl]-5-methyl-6-(2-hydroxyethyl)-4,5-dihydro-1,2,4-triazine (I). The inhibition by I was recovered competitively and specifically by thiamine. The inhibition index for L. fermenti was 9480 and that for Kl. apiculata was 41100. The growth of Sacch. carlsbergensis 4228 was stimulated by I of PT-B_1,2-phenyl-4-[(2-methyl-4-amimo-5-pyrimidinyl)-methyl]-5-methyl-6-(2-hydroxyethyl)-2,5-dihydro-1,2,4-triazinium chloride (II) in low concentration but inhibited by them in high concentration. This growthinhibitory effect by I was recovered specifically by addition of pyridoxine but the inhibition by II was not recovered by any vitamin.View full abstractDownload PDF (451K) -
Choten INAGAKI, Kanako KAWAGUCHIArticle type: Article
1966 Volume 34 Issue 3 Pages 293-297
Published: September 25, 1966
Released on J-STAGE: February 09, 2018
JOURNAL FREE ACCESSIn order to compare the metabolism of L-ascorbic acid with that of its fatty acid esters, the amounts of ascorbic acid in urine, liver, adrenal and blood plasma of guinea pigs were determined after the oral administration of L-ascorbic acid, L-ascorbyl mono- and dipalmitates, equivalent to 20mg of ascorbic acid. In three groups, the urinary ascorbic acid excreted in 0-24 hrs. after administration was higher than that in 24-48 hrs. The changes of ascorbic acid content of the organs showed the similar tendency with that of urine in group of ascorbic acid administration, but in groups of esters administration, the changes showed a somewhat reverse tendency. Enzymatic hydrolysis of ascorbic acid ester was also studied with tissue homogenate of guinea pig. When the mixture of homogenates of small intestine and pancreas was used, the yields of free ascorbic acid were 80% with L-ascorbyl monopalmitate but only 20% with L-ascorbyl dipalmitate.View full abstractDownload PDF (636K) -
Michiko TSUBOSAKAArticle type: Article
1966 Volume 34 Issue 3 Pages 298-303
Published: September 25, 1966
Released on J-STAGE: February 09, 2018
JOURNAL FREE ACCESSIn previous paper, it was shown that toxopyrimidine is phosphorylated by partially purified pyridoxal kinase in mouse brain to toxopyrimidine phosphate. In present report, the author tried to clarify whether the phosphorylations of pyridoxal and toxopyrimidine are catalysed by the same enzyme or not using highly purified preparation. It was concluded that the kinase is able to phosphorylate the both substrates since the heat stabilities, metal requirements, behaviors for inhibitors almost coincide in both activities.View full abstractDownload PDF (666K) -
Seiji ISHIKAWA, Kiyoshi MASANI, Goichiro KATSUIArticle type: Article
1966 Volume 34 Issue 3 Pages 304-307
Published: September 25, 1966
Released on J-STAGE: February 09, 2018
JOURNAL FREE ACCESSThe red substances were isolated from the soybean oil in color reversion and also from the sludge obtained in deodorizing procedure of soybeen oil. They were identical with the tocored-1 which is one of the oxidation products of α-, and γ-tocophrols in reaction with HNO_3,or FeCl_3 in thin layer chromatography, UV-Vis spectrum and IR spectrum. It cannot be concluded that the color revertion is due to the tocored-1 only, but it seems to be true that the tocored-1 takes great part in color reversion of soybean oil.View full abstractDownload PDF (465K) -
Eiko INAHARAArticle type: Article
1966 Volume 34 Issue 3 Pages 308-313
Published: September 25, 1966
Released on J-STAGE: February 09, 2018
JOURNAL FREE ACCESSThe hepatic cells of newborn mice aged from 2 to 7 day-old were observed with the electron microscope and following results were obtained. 1) The development of Golgi apparatus obtained from the samples of 2 and 3 day-old mice was highly good. 2) The 3 day-old mice revealed the most striking appearance of lipid droplets. 3) The development of microvillus was recognizable throughout the newborn period. 4) The remainder of intracellular organelle did not show any significant difference corresponding to the age in days during the newborn period.View full abstractDownload PDF (2880K) -
Eiko INAHARAArticle type: Article
1966 Volume 34 Issue 3 Pages 314-321
Published: September 25, 1966
Released on J-STAGE: February 09, 2018
JOURNAL FREE ACCESSVitamin K_4 (Synkavit) was given in large dose of 0.1 to 0.7 mg for the mice of 1 to 7 day-old and following results were obtained. 1) When 0.3 mg or more of vitamin K_4 was injected to the mice within a week, the hair was stained to yellow and the body weight was not gained too much. 2) When 0.2mg was injected within the first 24 hours for newborn mice, the survival rate at 2 day-old was 30.8% and this difference was statistically significant in comparison with the groups of vitamin K_1 and control. 3) The rough surfaced endoplasmic reticulum was lost of normal stratiform arrangement, and was splitted, vesiculated and enlarged. 4) The limiting membrane of mitochondria was saw-toothed, and its shape was irregular, looked like a worm-bitten. The size was enlarged and expanded or giantic. In the mitochondrial matrix, the changes of myellin like figures were recognized. 5) The lysosome of various forms appeared very frequently and the cytolysomes were also recognized. 6) The Golgi apparatus was very well developed, particularly, numerous at the periphery of the bile canaliculi, and the pattern of increased secretion were noted.View full abstractDownload PDF (4834K) -
Eiko INAHARAArticle type: Article
1966 Volume 34 Issue 3 Pages 322-327
Published: September 25, 1966
Released on J-STAGE: February 09, 2018
JOURNAL FREE ACCESSVitamin K_1 was given to the mice of 1 to 7 day-old in the dose of 0.1 to 0.7 mg and following results were obtained. 1) Though vitamin K_1 of 0.1 to 0.7 mg in total was given to mice, the change in hair colour to yellow did not occur and the body weight increased normally. Even when the dosage was further increased, the hair colour of mice did not turn to yellow. 2) The rough surfaced endoplasmic reticulum kept the normal stratiform arrangement, and distributed evenly over the whole cytoplasm without noticeable changes. 3) The shape of mitochondria was generally round or elliptic, and was not differ from the normal condition. However in the mitochondria of 3 day-old mice given 0.3 mg of vitamin K_1,the metamorphosis was recognized. 5) In the 2 day-old mice, the development of Golgi apparatus was very good. In the other mice no remarkable difference was recognized compared with the control group.View full abstractDownload PDF (2977K) -
Kunihei INAZU, Ryuichi YAMAMOTOArticle type: Article
1966 Volume 34 Issue 3 Pages 328-333
Published: September 25, 1966
Released on J-STAGE: February 09, 2018
JOURNAL FREE ACCESSIn an aqueous solution, sulpyrine caused significant increase in the rate of destruction of thiamine in a pH range of 3-7. This reaction was shown to proceed at an increasing rate with decreasing of acidity, though the effect of pH diminished as the pH passes 5. Activation energy for this reaction has been measured to be 27 kcal/mole and the salt effect was neglegible. Isolation of the decomposition products and the other experimental evidence showed that bisulfite from sulpyrine caused the replacement reaction of thiamine with the basic moiety of sulpyrine and that the rate of this reaction was dependent of bisulfite concentraton. The replacement reaction product, 4-N-methyl-N-[2-methyl-4-aminopyrimidyl-(5)] aminoantipyrine, was compared with sulpyrine in regards to the acute toxicity, the analgesic and the hypothermal activities.View full abstractDownload PDF (712K) -
Kunihei INAZU, Ryuichi YAMAMOTOArticle type: Article
1966 Volume 34 Issue 3 Pages 334-336
Published: September 25, 1966
Released on J-STAGE: February 09, 2018
JOURNAL FREE ACCESSBased on the previous findings that the bisulfite from sulpyrine caused the replacement reaction of thiamine with the basic moiety of sulpyrine and that the reaction rate was dependent of bisulfite concentration in the system, stabilization of thiamine in the presence of sulpyrine was successfully attempted with the addition of HCHO or HCHO donators such as hexamethylenetetramine. This success may be attributable to decrease in the bisulfite concentration owing to the formation of formaldehyde sodium bisulfite. Partial oxidation of bisulfite in the reaction mixture resulted also in the stabilization of thiamine.View full abstractDownload PDF (384K) -
Morio KANNO, Toshio IMAGAWA, Tsuneyoshi TANABEArticle type: Article
1966 Volume 34 Issue 3 Pages 337-343
Published: September 25, 1966
Released on J-STAGE: February 09, 2018
JOURNAL FREE ACCESSThe relation of the chemical structure of thiamine alkyldisulfides to the positive inotropic action was studied by using isolated guinea pig atria. From the results obtained, it was suggested that the S-S bond of thiamine alkyldisulfides is indispensable for the production of the positive inotropic action. The antagonistic action of thiamine tetrahydrofurfuryldisulfide (TTFD) against metabolic inhibitors was also studied and it was confirmed that TTFD antagonizes the depression of atrial contraction induced by meralluride and pentobarbital. Depression of atrial contraction due to dinitrophenol or cyanide was antagonized by TTFD to some extent. However, TTFD was incapable of antagonizing the depression caused by monoiodoacetic acid. As a result of perfusion experiments on the isolated guinea pig heart, it was shown that the ventricle increased its contractile force by TTFD only when a perfusion fluid containing blood cells was used. In the case of a perfusion fluid lacking blood, a negative inotropic action was induced by TTFD. Thus, it was suggested that thiamine alkyldisulfides show different patterns of cardiac action with metabolic changes in heart muscles.View full abstractDownload PDF (980K) -
Kichi UEDA, Masakazu KAWAIArticle type: Article
1966 Volume 34 Issue 3 Pages 344-348
Published: September 25, 1966
Released on J-STAGE: February 09, 2018
JOURNAL FREE ACCESSThe intraperitoneal injection of homopantothenic acid (HOPA) was effective to reduce the excitation, tremor and death rate of rats induced by the cutaneous application of dichlorodiphenylpentachloroethane. The simultaneous administration of HOPA and pyridoxal phosphate was more effective than the widely recommended drug, phenebarbital. HOPA showed the remarkable inhibition of spastic convulsion and immediate death-rigor in cutaneous pentachlorophenol poisoning in rats.View full abstractDownload PDF (687K) -
Shoichi YAMAGATA, Yoshio GOTO, Masanori MITA, Jin KIKUCHI, Yuichi YAMA ...Article type: Article
1966 Volume 34 Issue 3 Pages 349-356
Published: September 25, 1966
Released on J-STAGE: February 09, 2018
JOURNAL FREE ACCESSThe curative effects of orally given hydroxocobalamin were examined in 25 diabetic outpatients with persistent manifestations of subjective signs of diabetic neuropathy and /or decreased motor nerve conduction velocity (MNCV) of ulnar nerve. In most of the cases, 1500μg of hydroxocobalamin was given as a daily dosis for 14-127 days. In few cases, 3000μg was given every day. An improvement of subjective signs of nervous disorders and changes in tendon reflex, calf tenderness and MNCV were used as indicators of the curative effects. Curative effects of hydroxocobalamin were more remarkable in 4-5th decade-diabetics with shorter duration of the disease and also in mild diabetics with good control of the disease. The drug was less effective in cases with advanced diabetic vascular complications. A significant elevation of MNCV was observed 11 of the 25 cases after the hydroxocabalamin therapy. In most of the cases, an amelioration or a disappearance of neuralgic pain, of paresthesia and of the symptoms of autonomic nervous dysfunctions was seen during the treatment.View full abstractDownload PDF (1003K) -
Katsuhiko FUJII, Shoichi SHIMIZU, Saburo FUKUIArticle type: Article
1966 Volume 34 Issue 3 Pages 357-363
Published: September 25, 1966
Released on J-STAGE: February 09, 2018
JOURNAL FREE ACCESSIrradiation of α-lipoic acid dissolved in various aliphatic aldehydes (molar ratio 1 : 200 or 1000,respectively) with an ultraviolet lamp gave the following results : (1) A considerable part of α-lipoic acid was converted to β-lipoic acid. (2) Trimerization of aldehyde markedly took place only when aldehyde was irradiated in the presence of α-lipoic acid. (3) In the irradiated mixture of α-lipoic acid and an aldehyde with branched carbon skeleton, such as isobutyraldehyde, an unknown lipoic acid-active substance was detected. The results of elementary analysis, infrared spectrophotometry and other tests have postulated the structure as I. The trimerization of aldehyde as well as the formation of the lipoic acid-active substance mentioned above seems to be initiated by the formation of an energy transfer complex of activated aldehyde with α-lipoic acid or a charge transfer complex of lipoic acid-biradical or -ion radical with aldehyde.View full abstractDownload PDF (801K) -
[in Japanese], [in Japanese]Article type: Article
1966 Volume 34 Issue 3 Pages 364-
Published: September 25, 1966
Released on J-STAGE: February 09, 2018
JOURNAL FREE ACCESSDownload PDF (176K) -
[in Japanese], [in Japanese], [in Japanese]Article type: Article
1966 Volume 34 Issue 3 Pages 364-365
Published: September 25, 1966
Released on J-STAGE: February 09, 2018
JOURNAL FREE ACCESSDownload PDF (356K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...Article type: Article
1966 Volume 34 Issue 3 Pages 365-
Published: September 25, 1966
Released on J-STAGE: February 09, 2018
JOURNAL FREE ACCESSDownload PDF (229K) -
[in Japanese], [in Japanese]Article type: Article
1966 Volume 34 Issue 3 Pages 365-
Published: September 25, 1966
Released on J-STAGE: February 09, 2018
JOURNAL FREE ACCESSDownload PDF (229K) -
[in Japanese], [in Japanese]Article type: Article
1966 Volume 34 Issue 3 Pages 365-366
Published: September 25, 1966
Released on J-STAGE: February 09, 2018
JOURNAL FREE ACCESSDownload PDF (374K) -
[in Japanese], [in Japanese]Article type: Article
1966 Volume 34 Issue 3 Pages 366-367
Published: September 25, 1966
Released on J-STAGE: February 09, 2018
JOURNAL FREE ACCESSDownload PDF (376K) -
[in Japanese], [in Japanese]Article type: Article
1966 Volume 34 Issue 3 Pages 367-
Published: September 25, 1966
Released on J-STAGE: February 09, 2018
JOURNAL FREE ACCESSDownload PDF (236K) -
[in Japanese], [in Japanese], [in Japanese]Article type: Article
1966 Volume 34 Issue 3 Pages 367-368
Published: September 25, 1966
Released on J-STAGE: February 09, 2018
JOURNAL FREE ACCESSDownload PDF (385K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese]Article type: Article
1966 Volume 34 Issue 3 Pages 368-
Published: September 25, 1966
Released on J-STAGE: February 09, 2018
JOURNAL FREE ACCESSDownload PDF (205K) -
[in Japanese]Article type: Article
1966 Volume 34 Issue 3 Pages 368-
Published: September 25, 1966
Released on J-STAGE: February 09, 2018
JOURNAL FREE ACCESSDownload PDF (205K)
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