Abstract
When O-benzoylthiamine disulfide (BTDS) was injected to mice at a dose of 20mg/kg (as thiamine) daily for 10 days, the incorporation of acetate-1^<14>C into hepatic cholesterol decreased, while that of mevalonic acid-2^<14>C was not influenced. An administration of 20mg/kg of BTDS suppressed the increases of blood and hepatic cholesterol in the diet with 1% cholesterol. The results suggest that BTDS may have the blood cholesterol-lowering effect by inhibiting the biosynthesis of cholesterol and enhancing the elimination of cholesterol.
