Abstract
Incorporation of O-benzoylthiamine disulfide (BTDS) into various organs of pregnant mouse and embryo was investigated using autoradiography after administration of ^3H-BTDS. ^3H-BTDS administered intragastrically was rapidly absorbed from duodenal epithelium and incorporated into the cells of various organs. The maximum concentration of labeled BTDS in the cells of various organs was observed over one to six hours after admimistration. But the incorporation of ^3H-BTDS into brain and heart was not so remarkable as the other organs throughout the course. Concerning the brain this might be related to blood-brain barrier. ^3H-BTDS was also incorporated rapidly into various organs of embryo with the maximum level over one to six hours after the administration. Liver and brain exceeded the other organs in incorporation of ^3H-BTDS.
