Abstract
Many drugs with anticancer activity are now used, clinically, but most of them show undesirable side effects. Attempts have been made to overcome the side effects with prophylactic drugs. Some clinicians have reported pyridoxine and its derivatives have prophylactic effects. Whether the administration of anticancer drugs cause the pyridoxine deficiency or not inhibit the tryptophanase activity was examined to rat. Anticancer drugs (Mitomycin-C, Thio-TEPA, Cyclophosamide, and Chlomomycin) did not cause significant change in pyridoxine content of liver, urinary excretion of xanthurenic acid after loading with tryptophan on albino rat, nor effect on tryptophanase activity in vitro.
