STUDIES ON THIAMINE DISULFIDE DERIVATIVES : (IV) PHARMACOLOGICAL ACTIONS OF O-ISOBUTYRYLTHIAMINE DISULFIDE

Abstract

Pharmacological effects of O-isobutyrylthiamine disulfide (iBuTDS) on experimental animals were studied as compared with those of thiamine hydrochloride (B_1-HCl). Acute toxicity of iBuTDS in mice was lower than that of B_1-HCl. On systemic blood pressure and respiration of dogs and rabbits, isolated vessels of rabbit's ear, excised intestine of guinea pigs and uteri of rabbits, in situ, the effects of iBuTDS were milder than or similar to those of B_1-HCl. The myocardial activity of isolated hearts of toads and rabbits was slightly stimulated by iBuTDS, while that effect was not observed in case of B_1-HCl.