Abstract
Riboflavin-2', 3', 4', 5'-tetranicotinate (mp. 147〜150℃) was synthesized by direct acylation of riboflavin with nicotinyl chloride and its chemical and physical properties were reported. Molar extinction coefficients of its benzene solution at 344,445 and 471 mμ were determined to be 8.5×10^3,12.5×10^3 and 9.7×10^3cm^<-1>M^<-1>, respectively. Emission maximum of the solution, when excited at 365 mμ, was found at 540 mμ. This compound was found to be soluble in various organic solvents, such as benzene, chloroform, alcohols, ketones, esters including triglycerides, dioxane, and so on. However, its solubility in water (at neutral pH) was somewhat less than that of riboflavin. It showed considerable resistance to photo-decomposition at neutral pH, compared with riboflavin.
