STUDIES ON THIAMIINE DISULFIDE : (XX) INTESTINAL ABSORTION OF THIAMINE DISULFIDE DERIVATIVES

Abstract

In the course of the studies on the metabolic pathway of TDS derivatives, absorption mechanism of TDS, BuTDS, and BTDS was investigated. Vitamins were administered in ligated rabbit intestine, and transferred thiamine derivatives in mesenteric venous blood were determined sparately with acylthiochrome fluorometry. In the venous blood collected immediately after administration of acyl TDS, main part of the total thiamine was found to be administered form. With the lapse of the time, the ratio of thiamine to total thiamine was gradually increased. These results showed that acyl TDS was absorbed from lumen with being administered form and metabolized to thiamine in gut wall and blood. Slightly different absorption mechanism of TDS was also discussed.