Abstract
The distributions of thiamine and its phosphates in rat's tissues, such as liver, heart and blood were determined, 30 minutes after the intravenous injection of either thiamine-^<14>C or thiamine propyldisulfide (TPD)-^<14>C at a dose of 1.5mg per 100g body weight. Thiamine, its di- and tri-phosphates (TDP and TTP) were separated by DEA・Sephadex A-25 column chromatography. As a result, free thiamine was found in largest amunt in tissues, followed by TDP, and TTP was found in small amount and TMP was not able to determined because of little amount. The injected TPD was taken up by heart tissue as thiamine and its phosphates more rapidly and in greater amount than in the case of thiamine injection.
