Abstract
Comparative study was made on acyl-TDS metabolizing ability of animals. OBT- and OBuT- deacylating activities were found to widely distribute in rabbit and rat tissues, such as liver, kidney, heart, intestine, brain, spleen and muscle. But the activities in rat tissues were much lower than in rabbit ones, especially in liver, kidney and brain. For the OBT esterase activity in blood, profound differences were found among man, dog, rabbit and rat. 100 ml of human blood was able to deacylate 25mg OBT to thiamine for ten minutes under the assay condition, and was 20- or 200-fold active than that of rabbit or rat blood, respectively.
