Abstract
Temporary increase of NAD content in the mouse liver after intraperitoneal injection of nicotinamide or nicotinic acid is wellknown. The increase of NAD content after intraperitoneal injection of α-tocopherylnicotinate was the same degree in case of the injection of nicotinic acid and less than nicotinamide. However, the maximum value of NAD content was attained at 12 hours after administration of the compound, and considerably higher than the normal value even after 24 hours. This fact shows that α-tocopherylnicotinate has more lasting action for the biosynthesis of NAD than nicotinic acid and nicotinamide.
