Abstract
The distribution of isobutyroylthiamine disulfide (iBuTDS) in the thiamine deficient rats with oral administration of small and large doses has been investigated histochemically by thiochrome fluorescent technique. It was observed that iBuTDS was incorporated into the various organs in much more amounts and mainly distributed in hepatic parenchymal cells, intestinal mucosa and muscle, cardiac muscle and cerebral nerve cells, comparing with the cases of thiamine hydrochloride. In cerebral nerve cells, the uptake of iBuTDS was gradually increased until 20 hours.
