STUDIES ON THIAMINE DISULFIDE DERIVATIVES : (VII) DISTRIBUTION AND EXCRETION OF O-ISOBUTYROYL-THIAMINE DISULFIDE-^<35>S

Abstract

The distribution and excretion of O-isobutyroylthiamine disulfide-^<35>S (iBuTDS-^<35>S) in male Wistar rats were studied, comparing with those of thiamine-HCl-^<35>S. The oral administration of iBuTDS-^<35>S raised the initial radio activity in blood and liver 2 to 3 times over than of thiamine-HCI-^<35>S, and later on until 72 hrs.maintained higher level of ^<35>S in various organs tested. In an earier time, the urinary excretion of iBuTDS-^<35>S was inferior to that of thiamine-HCl-^<35>S. No significant difference between iBuTDS-^<35>S and thiamine-HCl-^<35>S was found in fecal excretion, but it was observed that large amounts of ^<35>S were secreted in bile after the intravenous injection of iBuTDS-^<35>S.