Abstract
The intestinal transport of sugar was examined with thiamine or riboflavin-deficient rats and mice, using D-glucose, which is actively absorbed and metabolized and 3-O-methylgulcose which is actively absorbed but non-metabolized. In thiamine deficiency, the transport of glucose was drastically decreased when 100mg% of glucose was placed on mucosal side, in situ, whereas that of methylglucose showed only little decrease. In riboflavin-deficiency, the transport of methylglucose was markedly inhibited, while that of glucose showed only little inhibition. From these result, it may conclude that in thiamine-deficiency, the disturbance is much more considerable in the metabolism in epithelial cells than in the active transport of sugar, on the other hand in riboflavin-deficiency, the active transport is directly inhibited.
