STUDIES ON FATTY ACID ESTERS OF PYRIDOXINE : (III) SYNTHESIS OF PYRIDOXINE 5-OCTANOATE AND ITS PHYSICOCHEMICAL PROPERTIES

Abstract

Pyridoxine 5-octanoate was synthesized and its chemical and physical properties were studied. Molar extinction coefficient of its ethanol solution at 286.5mμ was 6.5 × 10^3 cm^<-1>mole^<-1>. It was soluble in various organic solvents such as benzene, chloroform, and ethanol, but its solubility in water was 0.273μmole/ml. Its solvent affinity was intermediate between pyridoxine and pyridoxine 3,4-dioctanoate. Pyridoxine 5-octanoate and pyridoxine 5-benzoate showed a weak vitamin B_6 activity for Saccharomyces carlsbergensis. Pyridoxine 5-octanoate was hydrolyzed completely in 0.055N H_2SO_4 at 126.5℃ for one hour.