Abstract
Absorption of fatty acid esters of pyridoxine (I) through everted sac of the rat intestine was studied. Pyridoxine 5-monoctanoate (II) and pyridoxine 3,4-dioctanoate (III) were hydrolyzed completely in the mucosal side, but pyridoxine 3,4-dilaurate (IV) was hydrolyzed only 5.5 % and pyridoxine 3,4-dipalmitate (V) was not. In the serosal side, the esters penetrated through the intestine were found to be (I) alone and no esters. The concentration of (I) in solution of the serosal side was the following order : (I)=(II)=(III)>(IV) and none for (V). There was a good correlationship between penetration through the everted sac of rat intestine, hydrolysis by homogenate of the rat intestine and solubility in a Krebs-Ringer's solution containing 10 % propylene glycol at pH 7.4. The penetration of esters of (I) was concluded that the esters were hydrolyzed in the intestinal fluid and (or) tissue and the resulted (I) penetrated through the intestine.
