Abstract
Concerning the fatty acid esters of riboflavin, many investigations for riboflavin-butyrates have been reported. Recently, the chemical synthesis of some novel riboflavin-2', 3'-dibutyrate and riboflavin-4', 5'-dibutyrate were accomplished by the Toa-Eiyo Chemical Industries Co., Ltd. Using vitamin B_2-deficient male rats, weighing 50〜60g, the prophylactic and curative experiments were carried out by oral administration with 30μg of the riboflavin-2', 3'-dibutyrate or 4', 5'-dibutyrate. The growth curves were recorded, and at the end of the experiments the incorporation of the vitamin into various tissues were estimated. The results indicated that riboflavin-2', 3'-dibutyrate and riboflavin-4', 5'-dibutyrate have marked metabolic activity than that of 2', 3', 4', 6'-tetrabutyrate.
