Abstract
The comparative study of the distribution of orally administered S-benzoylthiamin O-monophosphate-^<35>S (BTMP-^<35>S) and thiamine-^<35>S (B_1-^<35>S) at various times has been carried out by means of whole body autoradiography in adult mice and liquid scintillation countig in rats. The results revealed that the uptake of ^<35>S after the administration of BTMP-^<35>S was more rapid in various organs than that after the administration of B_1-^<35>S and higher levels of the radioactivity continued for a longer time in the case of the former than the latter. The difference was pronounced in particular in brain and muscles such as cardiac muscle or diaphragm, where the radioactivity remained for more than 92 hours after the administration. Paper chromatogram of the brain and heart extracts at 24 hours after the administration of BTMP-^<35>S showed the highest activity in thiamine diphosphate. The whole body autoradiographic method was applied for brain and heart removed from rabbit after the administration of BTMP-^<35>S and revealed the localization of radioactivity in gray matter rather than white matter in brain and an even distribution of radioactivity in cardiac muscle fibre.
