Abstract
The distribution of radioactivity has been studied by means of whole body autoradiography in mice, guinea pig, cockerel, young dog and monkey injected intramuscularly with O-butyryl-thiamine disulfide-^<35>S (BuTDS-^<35>S). The distribution of radioactivity in mouse 24 hours after injection of BuTDS-^<35>S was highly accumulated in liver, kidney, myocardium, salivary gland, masseter, gastrointestinal mucosa, brown fat, spinal ganglia, spinal cord and brain. The radioactivity in the lung, pancreas, skin and blood were lower than that in the other organs. The patterns of distribution of the radioactivity in the guinea pig and monkey were similar to that of the mice but the distribution pattern in cockerel was some difference from those in other animals. The remarkable accumulation of radioisotope in the liver, kidney, myocardium and gray matter of central nervous system were found for all of animals tested.
