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Volume 39 (1969)
- Issue 6 Pages 367-
- Issue 5 Pages 301-
- Issue 4 Pages 221-
- Issue 3 Pages 145-
- Issue 2 Pages 77-
- Issue 1 Pages 1-
Volume 39, Issue 4
Displaying 1-21 of 21 articles from this issue
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Toshio KURODA, Masakazu TAKEMURA, Mituharu AGATAArticle type: Article
1969 Volume 39 Issue 4 Pages 221-227
Published: April 25, 1969
Released on J-STAGE: February 17, 2018
JOURNAL FREE ACCESSO-Nicotinylthiamine disulfide (I) was synthesized by acylation of thiamine disulfide (II) with nicotinylchloride. It was also prepared either by direct reaction of II with nicotinic acid and ethylchloroformate, benzene sulfonylchloride. Its chemical and physical properties were reported. The compound is white, odorless and hygroscopic. The ultraviolet spectrum of the compound has its absorption maximum at 255mμ in acidic solution, which varies depending on pH of the solution. The infrared spectrum shows specific absorption band at 1720cm^<-1> (ν^<C=O>) and 1280cm^<-1> (ν^<C_O_C>). The compound is found to be stable in powdered form and is also stable in acidic solution than in neutral or alkaline solution.View full abstractDownload PDF (679K) -
Toshinobu SASAKI, Takaaki KIKUCHI, Toshio KURODA, Kenji MURAKAMIArticle type: Article
1969 Volume 39 Issue 4 Pages 228-231
Published: April 25, 1969
Released on J-STAGE: February 17, 2018
JOURNAL FREE ACCESSInvestigations were carried out on the pharmacological effects of O-nicotinylthiamine disulfide (NTDS). The doses for mouse were 12.2 g/kg in oral administration and 0.32g/kg in intravenous injection. On the cardio-vascular system, the blood pressure and respiration, NTDS acted similiarly to thiamine. NTDS had little effect on the isolated intestine of rabbit.View full abstractDownload PDF (539K) -
Keiichi KATOArticle type: Article
1969 Volume 39 Issue 4 Pages 232-235
Published: April 25, 1969
Released on J-STAGE: February 17, 2018
JOURNAL FREE ACCESSChanges in nicotinate concentration in blood and in urine of animals after the injection of riboflavin-2', 3', 4', 5'-tetranicotinate of which nicotinate moieties were uniformly labeled with tritium (B_2-Nic^*) were investigated in comparison with those of animals injected with uniformly labeled nicotinic acid (NiA^*). The rate of excretion of radioactivity into urine of animals injected with B_2-Nic^* was found to be considerably lower than that of animals injected with NiA^*, suggesting that esterified nicotinate was more accumulative in living body than free NiA. B_2-Nic^*, in contrast to NiA^*, showed no temporal change in radioactivity in the early stage after the injection, and showed a potency in keeping blood NiA level higher than the normal for a long time. It, therefore, suggests that this compound could be beneficially used as deposit type of NiA.View full abstractDownload PDF (454K) -
Tadao TAKAHASHI, Tetsuo KIMURA, Yoshishige SATOArticle type: Article
1969 Volume 39 Issue 4 Pages 236-243
Published: April 25, 1969
Released on J-STAGE: February 17, 2018
JOURNAL FREE ACCESSThe distribution of radioactivity has been studied by means of whole body autoradiography in mice, guinea pig, cockerel, young dog and monkey injected intramuscularly with O-butyryl-thiamine disulfide-^<35>S (BuTDS-^<35>S). The distribution of radioactivity in mouse 24 hours after injection of BuTDS-^<35>S was highly accumulated in liver, kidney, myocardium, salivary gland, masseter, gastrointestinal mucosa, brown fat, spinal ganglia, spinal cord and brain. The radioactivity in the lung, pancreas, skin and blood were lower than that in the other organs. The patterns of distribution of the radioactivity in the guinea pig and monkey were similar to that of the mice but the distribution pattern in cockerel was some difference from those in other animals. The remarkable accumulation of radioisotope in the liver, kidney, myocardium and gray matter of central nervous system were found for all of animals tested.View full abstractDownload PDF (2054K) -
Ichica YAMAGAMI, Yoshio SUZUKI, Mikio ITO, Hajime FUJIMURAArticle type: Article
1969 Volume 39 Issue 4 Pages 244-250
Published: April 25, 1969
Released on J-STAGE: February 17, 2018
JOURNAL FREE ACCESSThe effect of thiamine and its derivatives (TPD, TTFD, TDS, BuTDS and CCT) on the dermal connective tissue permeability in rats were tested by means of spreading method. Subsequently the effect of various anti-inflammatory agents combined with these vitamins on the tissue permeability were also tested. (1) Of these vitamins, TTFD only decreased significantly the tissue permeability with subcutaneous or oral administration. (2) When Na-salicylate was combined with several graded doses of thiamine and its derivatives, its inhibitory effect was reached to peak in combination with a dose of 100mg/kg s.c. or 200 mg/kg p.o. of thiamine, whereas a dose of 25 mg/kg s.c. or 50mg/kg p.o. of TPD or CCT and 10mg/kg s.c. or 20 mg/kg p.o. of TTFD. (3) When various anti-inflammatory agents were combined with either vitamin described above, the potentiations of the inhibitory effect of them were observed.View full abstractDownload PDF (778K) -
Hideyuki MATSUURAArticle type: Article
1969 Volume 39 Issue 4 Pages 251-261
Published: April 25, 1969
Released on J-STAGE: February 17, 2018
JOURNAL FREE ACCESSMice were divided into 3 groups : first group was untreated, and the other two groups were irradiated with 200R of γ-rays of ^<60>Co on the 10th day of pregnancy. The third group was divided into 3 sub-groups which were treated intramusculary with 0.2,1.0,5.0 mg/day of vitamin E, respectively. Half of each group was treated from the 1st to 19th day and the other half was given the same doses of vitamin E after radiation from 10th to 19th day. The author has confirmed the fact that proper dosage of vitamin E could reduce mortality and incidence of malformation of the fetus and reduce the radiation injury of the placenta. The most effective result was obtained by the administration of 1.0 mg/day from the beginning of pregnancy.View full abstractDownload PDF (3745K) -
Hideyuki MATSUURAArticle type: Article
1969 Volume 39 Issue 4 Pages 262-266
Published: April 25, 1969
Released on J-STAGE: February 17, 2018
JOURNAL FREE ACCESSPregnant mice were irradiated by 200R of γ-ray of ^<60>Co on the 10th day of pregnancy and were administered continuously 1.0mg/day of vitamin E from the 1st day of pregnancy. Histological findings of the placenta of irradiated mice with vitamin E administration were investigated every two or three days in succession, comparing with those of control animals. In general, the irradiated placenta showed underdevelopment, degeneration and circulatory damage in its every layer and these changes were most manifest on the 4th day after irradiation. From the 6th day on these changes were gradually improved. These radiation injury of the placenta was reduced to some extent by the administration of vitamin E and its effect was noticed from the 2nd day after irradiation.View full abstractDownload PDF (1652K) -
[in Japanese], [in Japanese], [in Japanese]Article type: Article
1969 Volume 39 Issue 4 Pages 268-279
Published: April 25, 1969
Released on J-STAGE: February 17, 2018
JOURNAL FREE ACCESSDownload PDF (1244K) -
[in Japanese]Article type: Article
1969 Volume 39 Issue 4 Pages 279-280
Published: April 25, 1969
Released on J-STAGE: February 17, 2018
JOURNAL FREE ACCESSDownload PDF (261K) -
[in Japanese]Article type: Article
1969 Volume 39 Issue 4 Pages 280-281
Published: April 25, 1969
Released on J-STAGE: February 17, 2018
JOURNAL FREE ACCESSDownload PDF (271K) -
[in Japanese], [in Japanese], [in Japanese]Article type: Article
1969 Volume 39 Issue 4 Pages 291-
Published: April 25, 1969
Released on J-STAGE: February 17, 2018
JOURNAL FREE ACCESSDownload PDF (187K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...Article type: Article
1969 Volume 39 Issue 4 Pages 291-292
Published: April 25, 1969
Released on J-STAGE: February 17, 2018
JOURNAL FREE ACCESSDownload PDF (321K) -
[in Japanese], [in Japanese], [in Japanese]Article type: Article
1969 Volume 39 Issue 4 Pages 292-293
Published: April 25, 1969
Released on J-STAGE: February 17, 2018
JOURNAL FREE ACCESSDownload PDF (327K) -
[in Japanese]Article type: Article
1969 Volume 39 Issue 4 Pages 293-
Published: April 25, 1969
Released on J-STAGE: February 17, 2018
JOURNAL FREE ACCESSDownload PDF (189K) -
[in Japanese]Article type: Article
1969 Volume 39 Issue 4 Pages 293-294
Published: April 25, 1969
Released on J-STAGE: February 17, 2018
JOURNAL FREE ACCESSDownload PDF (339K) -
[in Japanese], [in Japanese], [in Japanese]Article type: Article
1969 Volume 39 Issue 4 Pages 294-
Published: April 25, 1969
Released on J-STAGE: February 17, 2018
JOURNAL FREE ACCESSDownload PDF (201K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese]Article type: Article
1969 Volume 39 Issue 4 Pages 294-295
Published: April 25, 1969
Released on J-STAGE: February 17, 2018
JOURNAL FREE ACCESSDownload PDF (346K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese]Article type: Article
1969 Volume 39 Issue 4 Pages 295-
Published: April 25, 1969
Released on J-STAGE: February 17, 2018
JOURNAL FREE ACCESSDownload PDF (198K) -
[in Japanese], [in Japanese]Article type: Article
1969 Volume 39 Issue 4 Pages 295-296
Published: April 25, 1969
Released on J-STAGE: February 17, 2018
JOURNAL FREE ACCESSDownload PDF (322K) -
[in Japanese], [in Japanese], [in Japanese]Article type: Article
1969 Volume 39 Issue 4 Pages 296-
Published: April 25, 1969
Released on J-STAGE: February 17, 2018
JOURNAL FREE ACCESSDownload PDF (176K) -
Takeshige YAMAKAWAArticle type: Article
1969 Volume 39 Issue 4 Pages 297-298
Published: April 25, 1969
Released on J-STAGE: February 17, 2018
JOURNAL FREE ACCESSDownload PDF (263K)
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