Abstract
The effects of vitamin B_6 on autooxidation of linoleic acid and denaturation of serum β-lipoprotein affected by liperoxide were investigated. Vitamin B_6 decreased autooxidation of linoleic acid with emulsion phase of 0.1M phosphate buffer at pH7.0,while showed no effect on the induction period of this system. Peroxide of ethyl linoleate had a marked effect on the stability of β-lipoprotein in human serum. In a study on the interaction between lml of human serum and 20mg of peroxide of ethyl linoleate, 2×10^<-2>M vitamin B_6 prevented serum β-lipoprotein from its denaturation and this preventive action was at least observed at a concentration of 2×10^<-6>M vitamin B_6. In vivo, treatment of vitamin B_6 decreased degree of serum TBA-reaction of patients with arteriosclerosis and albino rats. Those effects of vitamin B_6 are not seemed to be physiological but pharmacological.
