Relation of Thyroid Function to NAD Synthesis in Mouse Liver

Abstract

Effects of daily subcutaneous injection of antithyroid agents or thyroxin on change of the level of NAD in mouse liver after intraperitoneal injection of nicotinamide were examined. Injection of 1-methyl-2-mercaptoimidazole, an antithyroid agent, once a day for 2 weeks resulted in higher level of NAD for longer duration. Injection of thyroxin once a day for 8 days gave the contrary results; lower increase of NAD-level after injection of either nicotinamide or NiA. Effects of Some tranquilizers and central nervous system stimulants were also examined. Trifluoperazine, a tranquilizer, gave the similar results to reserpine, higher and longer increase of NAD after NiAA injection.