Abstract
The influence of glucocorticoid on the metabolism of B_2 was investigated. Various doses of prednisolone of 2 and 8mg/kg body weight for 3,7,14,21 days were injected into young albino rats. 1) Blood concentration of B_2 was slightly increased. 2) Hepatic concentration of B_2 was increased in the early stage, but decreased in the late stage. These tendencies were remarkably distinct in FAD fraction compared with other B_2 fractions. 3) B_2 concentration in the kidney and the small intestine did not show so remarkable changes as in the liver by the continuous use of glucocorticoid. 4) B_2 concentration of liver in adrenalectomized rats was slightly decreased, and the FAD fraction was reduced markedly.
