Biological and Coenzymic activity of Vitamin B_6 derivatives : (I) THE ACTIVITIES OF B_6 ANALOGUES MODIFIED AT 3 OR 5 POSITION OF PYRIDOXOL IN THE GROWTH OF SACCHAROMYCES CARLSBERGENSIS

Abstract

Several pyridoxol analogues modified at 3 or 5 position of the pyridine ring have been synthesized. 2-Methyl-3-amin0-4,5-dihydroxymethyl pyridine (3-amino POL) which has the substituent of NH_2 at 3 position of pyridoxol, inhibited strongly the growth of S. carlsbergensis 4228 (ATCC 9080) and the inhibition was reversed by the addition of pyridoxol. The 50% inhibition index of 3-amino POL was 35 while that of 4-deoxypyridoxol was 80〜90. (Received May 19,1972)