VITAMINS
Online ISSN : 2424-080X
Print ISSN : 0006-386X
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Volume 46, Issue 1-2
Displaying 1-26 of 26 articles from this issue
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  • Contribution of NMR spectroscopy to the chemistry of fat-soluble vitamins
    Kiyoshi TSUKIDA
    Article type: Article
    1972 Volume 46 Issue 1-2 Pages 1-18
    Published: August 25, 1972
    Released on J-STAGE: February 27, 2018
    DOIhttps://doi.org/10.20632/vso.46.1-2_1
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    Historical sketch and general considerations on NMR : analysis of fatsoluble vitamins are briefly reviewed. Several potential techniques for obtaining NMR data amenable to first-order analysis are described and special emphasis is given to the application of a paramagnetic shift reagent Eu(DPM)_3 in this field. Extensive data are accumulated with typical illustrations and future extension is prospected. (Received June 10,1972)
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  • Synthesis of Vitamin D_2 Tetra-Acetyl Glucoside (Ergocalciferyl 2,3,4,6-tetra-ο-acetyl-D-glucoside)
    Kazuo SHIRAI, Syunsuke YUYAMA, Makoto UENO
    Article type: Article
    1972 Volume 46 Issue 1-2 Pages 19-24
    Published: August 25, 1972
    Released on J-STAGE: February 27, 2018
    DOIhttps://doi.org/10.20632/vso.46.1-2_19
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    Vitamin D_2 tetra acetyl glucoside, was synthesized from D_2 and tetra acetyl glucosyl bromide by Koenigs-Knorr reaction. The chemical structure of the compound was ascertained from its elementary analysis. UV-, IR-, mass- or NMR-spectral analysis and reacetylation after deacetylation. Neither isomerization nor rearrangement in the process of synthetic treatment was observed. Further data on the solubility in ethanol and specific rotation were determined. Although water-solubilization of D_2 was the aim of this synthetic experiment, the D_2 glucoside was insoluble in water. (Received March 24,1972)
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  • Utilization of 4-Methyl-5-β-Hydroxyethylthiazole Monophoshate by a 4-Methyl-5-β-Hydroxyethylthiazole-Requiring Mutant of Escherichia coli
    Kimiko WATANABE-KUBA
    Article type: Article
    1972 Volume 46 Issue 1-2 Pages 25-32
    Published: August 25, 1972
    Released on J-STAGE: February 27, 2018
    DOIhttps://doi.org/10.20632/vso.46.1-2_25
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    A 4-methyl-5-β-hydroxyethylthiazole (Th) -requiring mutant strain of Escherichia coli 26-43,responded to either free Th or Th monophosphate in the growth medium of Davis and Mingioli. However, the amount of Th monophosphate required for a half-maximal growth of the mutant was observed to be approximately 30 times greater than that of Th. Additional experiments revealed that the mutant cells cleaved Th monophosphate into free Th and inorganic phosphate. The enzyme responsible for the conversion from Th phosphate to free Th was extracted from acetone powder of the cells and was identified as nonspecific acid phosphatase. It was suggested that Th monophosphate was hydrolyzed into Th at the surface of the cell membrane and utilized by the organism. (Received March 30,1972)
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  • Biosynthesis of Rutin Glucoside by Mucor javanicus
    Toshio MIYAKE, Yukio SUZUKI
    Article type: Article
    1972 Volume 46 Issue 1-2 Pages 33-36
    Published: August 25, 1972
    Released on J-STAGE: February 27, 2018
    DOIhttps://doi.org/10.20632/vso.46.1-2_33
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    It was found that rutin glucoside was formed in the incubation mixture containing maltose, rutin and a partially purified enzyme preparation from Mucor javanicus having the 5'-D-riboflavin-α-D-glucopyranoside-forming activity. (Received March 31,1972)
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  • Effect of Folate Coenzymes on Hematological Changes in Folate-deficient Rat
    Osamu OKINAKA, Makiko UMEZAWA, Hidenori SOTOBAYASHI, Kazuo IWAI
    Article type: Article
    1972 Volume 46 Issue 1-2 Pages 37-44
    Published: August 25, 1972
    Released on J-STAGE: February 27, 2018
    DOIhttps://doi.org/10.20632/vso.46.1-2_37
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    In rats, fed a folic acid-deficient synthetic diet containing sulfaguanidine, growth was retarded, and decreases in the red cell count and granulocyte count and a relative increase of hypersegmented neutrophils were noted. The administration of methotrexate (2 μg per day per rat, intramuscularly) for 3 days beginning on the 18th day of the experimental diet exaggerated these hematological changes. A single injection of tetrahydrofolic acid, 5-methyl-tetrahydrofolic acid or 5.10-methenyltetrahydrofolic acid (500lμg per rat) on the 21th day of the experiment resulted in increases in the red cell count and the granulocyte count, also in the normalization of distribution of nuclear segments in neutrophils on the 2nd day. Of all the compounds tested, tetrahydrofolic acid had the most potent effect. (Received April 22,1972)
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  • Effects of Ethanol on Intestinal Absorption of Vitamin B_&lt12> in Rats
    Haruyuki MATSUO, Keisuke YASHIMA, Kunio OKUDA
    Article type: Article
    1972 Volume 46 Issue 1-2 Pages 45-49
    Published: August 25, 1972
    Released on J-STAGE: February 27, 2018
    DOIhttps://doi.org/10.20632/vso.46.1-2_45
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    The effect of acute ethanol intoxication on the intestinal absorption of B_<12> was studied in the rat. Diluted ethanol was given by a stomach tube in a single dose of 1.8ml per 100 gram body weight and ^<57>Co-B_<12>(cyanocobalamin) was given 4 hours later. The controls received an isocaloric glucose solution. It was found that the descent of the dose from the stomach was markedly delayed in the ethanol group, necessitating a direct, transserosal instillation of ^<57>Co-B_<12> in the small intestine. Physiological doses of ^<57>Co-B_<12> with or without rat intrinsic factor concentrate, as well as a supraphysiological dose were given into the midportion of the small intestine and absorption was measured from the radioactivity recovered in the intestine and organs. It was shown that IF-mediated absorption of B_<12> was markedly impaired in the ethanol treated rats. The mucosal absorption of IF-B_<12> measured by washing the lumen shortly after administration was also impaired, but to a lesser extent than that of the reduction in overall absorption. Non-IF mediated absorption of ^<57>Co-B_<12> Was not affected under these conditions regardless of the dose, neither was the tissue uptake following parenteral administration of ^<57>Co-B_<12> altered. It was concluded that ethanol impairs the active trasnport system for B12 involving the IF mechanism. (Received April 22,1972)
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  • Growth of a Thiamine Requiring Mutant Strain of E. coli with the Thiamine Related Compounds
    Atsuko NAKANO, Haruko MAESHIMA, Teijiro MIYAMOTO, Kiku MURATA
    Article type: Article
    1972 Volume 46 Issue 1-2 Pages 51-57
    Published: August 25, 1972
    Released on J-STAGE: February 27, 2018
    DOIhttps://doi.org/10.20632/vso.46.1-2_51
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    The thiamine requiring strain of E. coli 70-23 showed a maximum growth in the Davis' culture medium with 10^<-10〜-11> mole/tube (final concentration of 2 x 10^<-8〜-9>M) of thiamine, but did not respond well in the medium containing both of pyrimidine and thiazole moieties of thiamine. However, in the existence of 2 x 10^<-5>M pyrimidinyl-nicotinic acid(Pm-NiA)or heteropyrithaimine (HPT), and of 2 x 10^<-4>M pyrimidinyl-cysteine (Pm-CySH) or its sulfoxide (Pm-CySH→O), the bacteria responded well. Pyrithiamine showed an antithiamine activity for growth of the bacteria at the concentration of 2 x 10^<-3>M, but was utilized by the bacteria at 2 x 10^<-4>M. The antithiamine activity was eliminated after preincubation for 48 hours or addition of 2 x 10^<-3〜-7>M thiamine. The existence of thiamine in the harvested bacteria grown in the Davis' culture medium with 2 x 10^<-5>M Pm-NiA was observed by thin layer chromato-graphy. The amount of thiamine was estimated by the microbiological assay with L. fermenti as 0.27 μg/g wet bacteria, which was around 10^<-3> times of concentration to the amount of thiamine in bacteria cultured in medium with 2 x 10^<-5>M thiamine. The mechanism of changes of the thiamine related compounds in the medium into thiamine by the bacteria during cultivation was discussed. (Received May 6,1972)
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  • Biological and Coenzymic activity of Vitamin B_6 derivatives : (I) THE ACTIVITIES OF B_6 ANALOGUES MODIFIED AT 3 OR 5 POSITION OF PYRIDOXOL IN THE GROWTH OF SACCHAROMYCES CARLSBERGENSIS
    Tatsuo OZAWA, Mitsuaki SANO, Isao TOMITA
    Article type: Article
    1972 Volume 46 Issue 1-2 Pages 59-63
    Published: August 25, 1972
    Released on J-STAGE: February 27, 2018
    DOIhttps://doi.org/10.20632/vso.46.1-2_59
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    Several pyridoxol analogues modified at 3 or 5 position of the pyridine ring have been synthesized. 2-Methyl-3-amin0-4,5-dihydroxymethyl pyridine (3-amino POL) which has the substituent of NH_2 at 3 position of pyridoxol, inhibited strongly the growth of S. carlsbergensis 4228 (ATCC 9080) and the inhibition was reversed by the addition of pyridoxol. The 50% inhibition index of 3-amino POL was 35 while that of 4-deoxypyridoxol was 80〜90. (Received May 19,1972)
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  • [title in Japanese]
    [in Japanese]
    Article type: Article
    1972 Volume 46 Issue 1-2 Pages 64-
    Published: August 25, 1972
    Released on J-STAGE: February 27, 2018
    DOIhttps://doi.org/10.20632/vso.46.1-2_64
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  • Clinical Effects of Vitamin E on Purpuras due to Vascular Defects
    Takaaki FUJII
    Article type: Article
    1972 Volume 46 Issue 1-2 Pages 65-70
    Published: August 25, 1972
    Released on J-STAGE: February 27, 2018
    DOIhttps://doi.org/10.20632/vso.46.1-2_65
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    The clinical effects of vitamin E were investigated in 7 cases (3 adolescents and 4 adults) of purpura due to vascular defects caused bv infection, drugs or unknown etiologies. In this study, marked clinical improvements following the oral administration of vitamin E (400 to 600mg of α-tocopherol nicotinate per day) were observed in all cases. Six out of 7 cases showed remarkable improvements of petechiae following the vitamin E therapy alone. Complete disappearance of petechiae was observed following the administration of vitamin E for 5 days in 2 cases, 14 days in 4 cases and 21 days in 1 dase, along with the improvements of other clinical sym ptoms . (Receiaed May 24,1972)
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  • [title in Japanese]
    A.K. Chatterjee, B.B. Ghosh
    Article type: Article
    1972 Volume 46 Issue 1-2 Pages 71-
    Published: August 25, 1972
    Released on J-STAGE: February 27, 2018
    DOIhttps://doi.org/10.20632/vso.46.1-2_71_1
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  • [title in Japanese]
    [in Japanese], [in Japanese]
    Article type: Article
    1972 Volume 46 Issue 1-2 Pages 71-72
    Published: August 25, 1972
    Released on J-STAGE: February 27, 2018
    DOIhttps://doi.org/10.20632/vso.46.1-2_71_2
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese]
    Article type: Article
    1972 Volume 46 Issue 1-2 Pages 72-
    Published: August 25, 1972
    Released on J-STAGE: February 27, 2018
    DOIhttps://doi.org/10.20632/vso.46.1-2_72_1
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese]
    Article type: Article
    1972 Volume 46 Issue 1-2 Pages 72-73
    Published: August 25, 1972
    Released on J-STAGE: February 27, 2018
    DOIhttps://doi.org/10.20632/vso.46.1-2_72_2
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese]
    Article type: Article
    1972 Volume 46 Issue 1-2 Pages 73-
    Published: August 25, 1972
    Released on J-STAGE: February 27, 2018
    DOIhttps://doi.org/10.20632/vso.46.1-2_73_1
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  • [title in Japanese]
    [in Japanese], [in Japanese]
    Article type: Article
    1972 Volume 46 Issue 1-2 Pages 73-
    Published: August 25, 1972
    Released on J-STAGE: February 27, 2018
    DOIhttps://doi.org/10.20632/vso.46.1-2_73_2
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  • [title in Japanese]
    [in Japanese]
    Article type: Article
    1972 Volume 46 Issue 1-2 Pages 75-
    Published: August 25, 1972
    Released on J-STAGE: February 27, 2018
    DOIhttps://doi.org/10.20632/vso.46.1-2_75_1
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  • [title in Japanese]
    [in Japanese], [in Japanese]
    Article type: Article
    1972 Volume 46 Issue 1-2 Pages 75-76
    Published: August 25, 1972
    Released on J-STAGE: March 14, 2018
    DOIhttps://doi.org/10.20632/vso.46.1-2_75_2
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  • [title in Japanese]
    [in Japanese]
    Article type: Article
    1972 Volume 46 Issue 1-2 Pages 76-77
    Published: August 25, 1972
    Released on J-STAGE: March 14, 2018
    DOIhttps://doi.org/10.20632/vso.46.1-2_76
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  • [title in Japanese]
    [in Japanese], [in Japanese]
    Article type: Article
    1972 Volume 46 Issue 1-2 Pages 77-
    Published: August 25, 1972
    Released on J-STAGE: March 14, 2018
    DOIhttps://doi.org/10.20632/vso.46.1-2_77_1
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    Article type: Article
    1972 Volume 46 Issue 1-2 Pages 77-78
    Published: August 25, 1972
    Released on J-STAGE: March 14, 2018
    DOIhttps://doi.org/10.20632/vso.46.1-2_77_2
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  • [title in Japanese]
    [in Japanese], [in Japanese]
    Article type: Article
    1972 Volume 46 Issue 1-2 Pages 78-79
    Published: August 25, 1972
    Released on J-STAGE: March 14, 2018
    DOIhttps://doi.org/10.20632/vso.46.1-2_78
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  • [title in Japanese]
    [in Japanese], [in Japanese]
    Article type: Article
    1972 Volume 46 Issue 1-2 Pages 79-80
    Published: August 25, 1972
    Released on J-STAGE: March 14, 2018
    DOIhttps://doi.org/10.20632/vso.46.1-2_79
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  • [title in Japanese]
    [in Japanese], [in Japanese]
    Article type: Article
    1972 Volume 46 Issue 1-2 Pages 80-
    Published: August 25, 1972
    Released on J-STAGE: March 14, 2018
    DOIhttps://doi.org/10.20632/vso.46.1-2_80_1
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    Article type: Article
    1972 Volume 46 Issue 1-2 Pages 80-81
    Published: August 25, 1972
    Released on J-STAGE: March 14, 2018
    DOIhttps://doi.org/10.20632/vso.46.1-2_80_2
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  • [title in Japanese]
    [in Japanese]
    Article type: Article
    1972 Volume 46 Issue 1-2 Pages 81-
    Published: August 25, 1972
    Released on J-STAGE: March 14, 2018
    DOIhttps://doi.org/10.20632/vso.46.1-2_81
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