Abstract
The distribution and metabolism of thiamine disulfide (TDS) in rat organs were compared with those of vitamin B_1 and O-n-butyryl TDS (BuTDS) by the use of ^<35>S-labeled compounds. In the present study we developed a column chromatographic method which enables to discriminate conveniently between the intact and the metabolites of these compounds. Total B_1 contents in various organs were higher than those of plasma or blood corpuscle 4 or 8 hours after the administration of TDS or BuTDS, and the characteristic distribution of TDS was similar to that of BuTDS but differed from that of B_1. All the three drugs were found in the liver with the highest concentration. This fact suggests that the liver probably plays an important role as a storage organ for these drugs.
