Effect of δ-Tocopherol on Bromidrosis

Abstract

Topical application of δ-tocopherol (δ-Toc) showed an excellent deodorizing effect on 34 patients of axillar bromidrosis. The clinical results suggest that δ-Toc, one of the most potent natural antioxidants, exerts the effect through its antioxidizing action, because the topical existence of iron in the appocrine gland of the patients is known to cause the oxidation of lipids and tocopherol itself. When 3% of d-δ-Toc in ethanol water solution (93 : 7) was applied, no irritation was observed on the applied region. In the case of patch test applied to 40 subjects if either irritable or healthy skin, no significantly positive reaction was observed. Thus, it would be concluded that the topical application of δ-Toc is very effective and natural treatment for bromidrosis.