Abstract
In the platelet-rich plasma from the thiamine deficient rats, platelet aggregation by ADP was not observed. This aggregation decreased as the thiamine deficiency progressed. By per os or subcutaneous administration of thiamine to the thiamine-deficient rats, the aggregation by ADP was restored. A factor or factors which inhibit platelet aggregation might exist in the plasma. Damaged aggregability of platelets from thiamine deficient rat was not recovered by the addition of thiamine, thiamine diphosphate and thiamine triphosphate in vitro but recovered by the addition of calcium chloride.
