Abstract
The relationship between amino acid metabolism and lipid contents in the liver of rats fed a vitamin B_6-deficient diet was studied. A high level of lipid in the liver of male rats fed a 70% casein-vitamin B_6-deficient diet was confirmed in the present paper. Female rats, on the other hand, failed to develop the fatty liver under a similar condition of high-protein-vitamin B_6-deficient diet. The degree of lipid accumulation in the liver of rats under various conditions of vitamin B_6-deficiency was found to be correlated with the degree of abnormal accumulation of free citrulline, serine and threonine in the liver.
