Abstract
Effects of vitamin B_2-butyrate and ubiquinone-10 (UQ_<10>) on adriamycin (ADM)-induced cardiac mitochondrial disorders were studied in male Wistar rats given daily injection of ADM (4 mg/kg body weight) for one week. Administration of ADM resulted in uncoupling of oxidative phosphorylation and in an increase of lipid peroxide of cardiac mitochondria. Measurement of UQ homologues in cardiac mitochondria by high-pressure liquid chromatography showed that UQ_<10> content decreased markedly after ADM administration. On the other hand, simultaneous administration of vitamin B_2-butyrate and UQ_<10> with ADM improved the oxidative phosphorylation activities and prevented the lipid peroxide formation of mitochondria, and furthermore restored the UQ_<10> content up to the normal level. Thus, combination therapy of both the vitamins was expected to prevent the ADM-induced cardiotoxicity during cancer chemotherapy.
