Effects of Vitamin B_1 and Vitamin B_6 on Respiration and Related Metabolism in Yeasts : (2) Alteration in Lipid Metabolism

Abstract

As described previously [Vitamins (Japan), 61, 93 (1987)], thiamine causes cytochrome deficiency and hence respiratory depression through vitamin B_6 deficiency in the cells of Saccharomyces yeasts. The cytochrome deficiency caused also alteration in lipid composition in S. carlsbergensis. Unsaturated fatty acid content was decreased and sterol composition was changed in the cells grown with added thiamine without supplementation of vitamin B_6, as expected from the participation of microsomal cytochromes in lipid metabolism. The effects of thiamine-induced cytochrome deficiency on lipid composition were abolished by concomitant addition of pyridoxine as in the case of respiratory depression.