1α-Hydroxycholecalciferol Prevents Osteoporosis Induced by Ovariectomy in the Rats

Abstract

We examined effects of 1α-OH-D_3 on bone loss in ovariectomized rats. Since bone mineral density of spines and femurs were decreased by ovariectomy, 1α-OH-D_3 significantly prevented bone loss in a dose dependent manner. 1α-OH-D_3 also significantly kept bone strength in femur to the normal levels. These effects were similar to those of 1,25(OH)_2D_3. Bone morphometric study showed stimulated bone resorption in the rats decreased by the administrations of 1α-OH-D_3. These results were suggestive that 1α-OH-D_3 shows preventions effects on osteoporosis due to inhibiting stimulated bone turn-over in the patients.