Antibacterial and Antifungal Actions with Iron(II) Complex of Vitamin C Analog (L-Threo-Hexo-2-Enaro-1,4-Lactone)

Abstract

L-Threo-hexo-2-enaro-1,4-lactone iron (II) complex [Fe(II)-S-AsA] and its ethyl ester-iron(II) complex [Fe(II)-ES-AsA] were prepared and examined for antibacterial and antifungal actions comparatively with ascorbic acid-iron (II) complex [Fe(II)-AsA]. These iron(II) complexes showed the respective strong antibacterial actions on Enterbactor aerogenes, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Bacillus cereus. [Fe(II)-S-AsA], [Fe(II)-ES-AsA] and [Fe(II)-AsA] showed antifungal action on Aspergillus niger, Geotrichum candidum, Aureobasidium pullulams, Penicillium steckii, and Trichoderma SP.