Abstract
With respect to the acute alcoholic liver injury in the mice by the administration of 86 mmol/kg of ethanol, 9.5 μmol/kg, 95 μmol/kg or 190 μmol/kg of flavin adenine dinucleotide (FAD) was administered to mice at 3 times before the administration of ethanol. The changes in the parameters, such as body weight, liver weight, flavin content, thiobarbituric acid reactive substances content and mitochondrial ADP/O ratio in the liver etc., by the administration of ethanol were dose dependently suppressed by FAD. It is suggested that an increase of lipid peroxidation and a decrease of mitochondrial ATP synthesis in the liver of mice caused by ethanol relate to the acute alcoholic liver injury. FAD shows a suppressive effect on the acute alcoholic liver injury by the decrease of lipid peroxidation and the restoration of mitochondrial ATP synthesis in the liver.
