1994 Volume 68 Issue 8 Pages 435-443
Changes in the contents of thiobarbituric acid reactive substances (TBARS), reduced glutathione (GSH) and flavin in the liver, mitochondrial ADP/O ratio and cytosolic enzyme activities, by the administration of 1.2 mmol/kg of trichloroethylene (TCE) or trichloroacetric acid (TCA) to mice were examined, and these changes were suppressed by the administration of flavin adenine dinucleotide (FAD). Then, the significant correlation between TBARS and ADP/O ratio, TBARS and flavin content, flavin content and ADP/O ratio, and TBARS and GSH content were observed. From these results, the liver injury by probably due to the lipid peroxidation induced by TCE or TCA is considered to be suppressed by the simultaneous administration of FAD.
