Abstract
This paper was summarized for my nutritional and physiological researches of some vitamins using deficient animals induced by unique methodologies. The first chapter deals the research for pantothenic acid deficiency of animals, microorganisms and some plants using its antimetabolites. ω-Methyl pantothenic acid and L(-)-pantothenic acid were useful antagonists for animals. The second chapter focus the role of intestinal flora on some vitamins, especially vitamin K and biotin, because the intestinal flora produce these vitamins. Germfree mice were used for these deficient experimental animals. Newly developed model for vitamin K deficiency was established. The primary biotin deficiency was also confirmed without egg white intake. The third chapter deals the studies concerning ascorbic acid using scurvy-prone ODS (osteodefect Shionogi) rat. We have carried on the studies for the nutritional physiology of trace elements such as vanadium and titanium. ODS rat have enabled us to approach the aspect of an ascorbic acid requirement study ; not only the study of ascorbic acid itself but also studies responsible for ascorbic acid.
