Abstract
Antimicrobial resistance (AMR) has become a serious threat to the prevention of an ever-increasing range of infections caused by bacteria, viruses, and so on. ‘One Health’ is an approach to designing and implementing programs, policies, and research in which multiple sectors communicate and work together to achieve better public health outcomes. In animal production, some of important AMR in human medicine are often detected in livestock. Therefore, it is important to use antimicrobials carefully in livestock. However, opportunistic infections are caused by increasing of stress and immune function disorder occurs often and these events could result in bovine respiratory disease complex (BRDC) in calves and peripartum disorders in dairy cows. Vital measures for these disease and disorder may be reducing stress, enhancing stress tolerance, and regulating the immune function by use of functional nutrients. In this report, we focused on the functions of α-tocopherol (α-Toc) in cattle. Namely, we investigated the expression of α-Toc-associated genes, the tissue accumulation ofα-Toc, and the effects of α-Toc supplementation on the stress response and the peripheral and respiratory immune functions in cattle. We try to discuss the prevention of the disorders in cattle from a standpoint of the nutritional and physiological research.
