酸化グラフェン上への脂質二重膜形成と膜内ドメイン局在化

抄録

Graphene oxide (GO) causes unique phenomena in the adsorption, structural transformation, and intramembrane domain distribution of lipid bilayer membranes. The amphiphilic surface property of GO because of nanoscale patches of pristine graphene and oxygen-functionalized regions affects the assembly of amphiphilic lipid molecules in the bimolecular membrane. Spherical vesicles of phosphatidylcholine (PC) transformed to a single bilayer, doubly stacking bilayer, or intact vesicles on GO depending on the surrounding condition. In a binary lipid bilayer comprising PC and a lipid tagged with polyethylene glycol (PEG), the domain of the PEG-tagged lipid preferentially localized on GO. The results about the interaction between GO and artificial lipid bilayer membranes provide fundamental information for understanding compatibility and/or toxicity of GO on cells and organelles.