The Development Research of Oxidase Functional Model Iron Complexes

Abstract

  This paper describes research performed in the Laboratory of Organic Chemistry, Showa Pharmaceutical University. Oxidation reactions involving the oxidase can be divided roughly into two kinds of reactions: The first involves electron removal from an aromatic ring or an active CH-bond. The other reaction involves hydrogen abstraction from an inactive CH-bond. The oxidase models, Fe(DMF)₃Cl₂¹⁺ and Fe(AN)₆³⁺/AN, which we have synthesized, have been shown to work by the former mechanism, and the models Fe(AN)₆³⁺-IO₄^-/AN, Fe(AN)₆²⁺-Ac₂O-H₂O₂/AN, Fe(AN)₆²⁺-2PAH-5Py-Ac₂O-H₂O₂/AN, Fe(PA)₃(OH₂)-H₂O₂/AN and Fe(PA)₃(OH₂)-O₂-electrolysis/AN do so by the latter mechanism. Further, we found some iron(II or III)picolinate-H₂O₂/AN complexes have the 7α-hydroxylase-like activity.