生理活性物質の合成研究 : プロスタサイクリン安定類縁体の合成を中心として

柴崎 正勝

doi:10.1248/yakushi1947.101.12_1073

Synthetic Studies on Prostacyclins : Thromboxanes and Polycyclopentanoides

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Keywords: prostacyclin, 9 (O)-thiaprostacyclin, 9 (O)-methanoprostacyclin, carbon analog of Δ⁶-PGI₁, sulfur analog of Δ⁶-PGI₁, thromboxane A₂, 6-oxabicyclo-[3.1.1] heptane skeleton, coriolin, hirsutic acid C, α-haloalkylstannanes, hydrostannation, β-lactam antibiotics

JOURNAL FREE ACCESS

1981 Volume 101 Issue 12 Pages 1073-1091

DOI https://doi.org/10.1248/yakushi1947.101.12_1073

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Abstract

The present article describes our recent synthetic studies on various biologically active compounds, including synthesis and biological properties of prostacyclins, synthetic approach toward thromboxanes, and total syntheses of coriolin and hirsutic acid C. In the final part of this review, some new reactions, exploited in connection with synthetic studies on prostacyclins, are also described.

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